The field of STEM has historically favoured male predominance and patriarchal values over placing due value and recognition to women who have and continue to contribute significantly in many ways. At its core, the subtle (and sometimes explicit) adversities that women face in their route to academic and career success, have rarely been addressed. Here, we offer a finely curated list of fool-proof tips to empower women and girls not only to better navigate the world of STEM but thrive in it.